glutathione and detoxification Role of S-transferases in of a polycyclic aromatic hydrocarbon, methylcholanthrene Glutathione: Master Antioxidant, Reducing Oxidative

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For example, numerous studies have established that mutations in LRRK2 confer susceptibility to mycobacterial infection, implying that LRRK2 plays a role in regulating immunity (Zhang et al., 2009

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Small-molecule inhibitors of cGAS enzymatic activity (e.g., RU.521, G140, PF-06928215) or STING signaling (e.g., H-151, C-176) have shown promise in preclinical neuroinflammation and neurodegeneration models by suppressing excessive type I interferon and cytokine production [12, 196]

10.3390/biomedicines11030783 14 ChenY.GuoS.JiangK.WangY.YangM.GuoM

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